On this week’s podcast we continue our discussion on the cholesterol lowering medications called statins. In part 1, we discussed the history of the low fat/low cholesterol dietary recommendations, how those were used to prop up the use of statins, and why that has been devastating to the health of the entire nation. In part 2, we discuss the literal mechanism of action of statin medication.
Statins are designed to inhibit the enzyme HMG CoA Reductase. This is one of the many enzymes needed for our body to produce cholesterol. However, blocking this enzyme not only inhibits our bodies ability to produce cholesterol, it also inhibits our bodies ability to produce things such as Isopentyl-PP, Farnesyl-PP and CoQ-10. These molecules play a number of important roles in the body. Farnesyl-PP is responsible for promoting proper insulin signaling, which is required to stay insulin sensitive, to prevent diabetes. Isopentyl-PP is responsible for the production of the master antioxidant glutathione, a powerful tool our body uses to fight off the damage done by free radicals. CoQ10 is a pivotal component of the electron transport chain which is needed for every cell in our body to produce adequate energy to stay alive. All of these functions are required to maintain proper health, yet statins inhibit these processes and make us sicker and weaker in the process.
To learn more about all the harmful effects of statins and why focusing on lowering cholesterol is the wrong approach for heart health, listen to this week’s podcast.
Articles Referenced on Podcast
Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms
177. STATINS: A DISTURBING STUDY ABOUT ADVERSE SIDE EFFECTS
Cholesterol & heart disease – there is a relationship, but it’s not what you think
How statin drugs really lower cholesterol & kill you one cell at a time
Study Links Statins to 300+ Adverse Health Effects
Comparison of mechanism and functional effects of magnesium and statin pharmaceuticals
Statin use may fast increase risk of diabetes, skin infections
Four cases of tendinopathy in patients on statin therapy
Statin-associated myopathy with normal creatine kinase levels
People With High Cholesterol Live Longer
Total Cholesterol and Heart Health